Terrorist activities in the Southern part of Africa is likely to increase ...

March 03, 2013

? The Editor World News Tomorrow ?

WORLD NEWS TOMORROW ? LONDON.- A new security vulnerability study of Southern African regions done by the? European Centre for Information Policy and Security? (ECIPS) found that Terrorist activities in the Southern part of Africa is likely to increase its footprint. The European Centre for Information Policy and Security ? ECIPS-? said Friday that this poses a risk factor for several western countries in particular for the European Union? and the Unites states.

The ECIPS (European Centre for Information Policy and Security) indicated that they would like to see if the upcoming Bricks event in South Africa would address any, if any, of these issues, such as terrorism in their backyard ?

Although Terrorism activities are largely playing a role towards the intimidation of western policies, the ECIPS said that the Asian countries such as? China, South Korea and Japan? might in future become at risk due to their high dependence on mineral resources from Africa and that Asian countries are certainly not immune to these risks, some experts said.

The ICSR ( International Centre for the Study of Radicalism ) London,? recently published a report that indicates that al-Qaeda could indeed partake in illicit and unregulated trade in Southern Africa to sustain itself?. There are several indications that the diamond trade is the most venerable to infiltrations of terrorist organization since 1997.

According to some security threat analysts,? the financial stability of Israel and Belgium could be largely effected should these threats not been further addressed by African governments as part of their policy in a global effort in the fighting of terrorism activities.

We must not forget that China is the largest consumer of Diamonds and consumes approximately 62% of the worlds diamonds and therefore these threats should not be undermined by Asian policy makers.

The European Centre for Information Policy and Security (ECIPS) said that there is still time to address these threats and that African countries have to realize that they are just? ?Economical Puppets? in a world of terror in this whole affair.

Failing to address these growing international concerns could lead to economical instability in the Southern part of Africa and effect all countries dependent on mineral resources from Africa.

Exclusive For World News Tomorrow By James Lee ? Africa ?

Source: http://www.worldnewstomorrow.com/?p=4510

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Vanessa Hudgens to Cosmo: I'm a Total Gypsy Bohemian!

Source: http://www.thehollywoodgossip.com/2013/03/vanessa-hudgens-to-cosmo-im-a-total-gypsy-bohemian/

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Best Buy Beats Estimates! 'In Joly We Trust' Says ... - Yahoo! Finance

One day after Best Buy (BBY) founder Richard Schulze pulled his plans to make an offer for the chain the company posted results well ahead of Wall St estimates, sending the stock soaring in pre-market trading.

For the all important holiday quarter BBY posted adjusted EPS of $1.64 on $16.7b in revenue compared to expectations of $1.54 and $16.4b. CEO Hubert Joly was pleased with the results but cautioned that 2014 would be a "year of transition". To that end Best Buy will ramp up SG&A with special attention paid to revamping the on-line division.

While refusing to offer financial guidance Joly laid out 6 areas of focus for the company. Investors can use these as a way to gauge Best Buy's progress. These priorities are 1) grow on-line sales 2) improve multi-channel selling 3) increasing sales and profits per square foot 4) driving down costs in the supply chain 5) optimizing the real estate portfolio [most likely by closing stores] 6) reducing SG&A expenses [cutting HQ staff].

Author, analyst and friend of Breakout Hitha Prabhakar says Schulze not being able to fund a buyout is the best outcome for all concerned. In the attached video Prabharkar explains that there's no magic bullet for the troubled electronics retailer but Joly's Renew Blue strategy deserves a chance.

"At this point I would say 'in Joly we trust,'" Prabhakar says of Schulze. Joly is reducing headcount in the home office rather than stores, increasing training and has apparently succeeded in stopping the bleeding, if not restoring the chain to full health. It may not be enough to return Best Buy to its former glory, but the Joly plan is about the best choice of the known options.

In the mid-teens Best Buy is too expensive to earn a large enough premium for Schulze to get control at a decent price. The smart play is for Schulze to sit back and watch. He's got billions invested in the company already. If Joly's plan works, Schulze will get even richer. If Renew Blue is a flop, Schulze can swoop in at a lower price. A buyout at these prices is the highest risk play with a limited upside potential.

As for shareholders it depends on their time frame. The buy & hold set should be aware there's a decent chance the stock will take a hit on no offer but its unlikely to be catastrophic. "I think it's worth taking a hit on the stock just to see what they're about to do," is how Prabhakar puts it.

Short term trading types may just want to mosey on to other ideas. The animal spirits of the market took over the day to day fluctuations in BBY stock long ago. Taking long or short positions and hoping something goes your way is a recipe for losing money.

Source: http://finance.yahoo.com/blogs/breakout/best-buy-goes-alone-joly-trust-way-forward-123543489.html

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Tackle Online Marketing Effectively With These ... - We Want CSG

If you?re attempting to open and operate an online business in today?s modern age of computing, then the Internet marketing techniques you implement need to be sound and effective in order to experience business growth. If your tactics aren?t updated and aren?t carried out with precision, then the end result is most likely going to be failure. Following are some great online marketing tips and techniques.

Put yourself in your customers? shoes. Does it offer ease of use? Does it engage your customers? Is it easy to place orders? It is useless to work hard to bring customers to your site through SEO and then lose them (and a sale) because your website is dull or confusing.

Look around to discover who your target audience is, and what sorts of things they respond well to. Now that you know who your target audience is, it will be easy to find the information that will encourage them to access your site time and again.

Updating content frequently is one of the best things you can do to capture the attention of the search engines. If someone visits your site and the information is outdated, they may assume that the company is not doing well and that it is a waste of time for them to contact you. An updated, well-managed site makes customers feel more engaged and welcomed.

TIP! Use this excellent internet marketing advice! Your landing page should have a clear sales message. Your site is about selling the product.

Always try to give an extra bonus to your customer when you ship their purchase. It might be a free sample or a discount coupon for future purchase. Clients really appreciate these types of coupons and often become repeat customers.

Affiliate marketing ventures will not succeed through chance, only through deliberate effort and hard work can you hope to enjoy success. There is no such story about a business that just got lucky in their success. Is the overwhelming success of the Coca-Cola brand a fluke? We know that is not the case. They used skill and effort to effectively market their product.

Now that you just learned a bit about Internet promotion, you can take what you learned here and look for ways to integrate it into your business. With a little effort and patience, the steps you take through affiliate marketing are sure to lead to a more successful business.

Source: http://www.wewantcsg.org/tackle-online-marketing-effectively-with-these-suggestions

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Misplaced molecules: New insights into the causes of dementia

Public release date: 1-Mar-2013
[ | E-mail | Share ]

Contact: Dirk Frger
presse@dzne.de
0049-228-433-02260
Helmholtz Association of German Research Centres

Shortage of protein TDP-43 causes muscle wasting and stunted nerve cells

This press release is available in German.

A shortage of a protein called TDP-43 caused muscle wasting and stunted nerve cells. This finding supports the idea that malfunction of this protein plays a decisive role in ALS and FTD. The study is published in the "Proceedings of the National Academy of Sciences of the USA" (PNAS).

ALS is an incurable neurological disease which manifests as rapidly progressing muscle wasting. Both limbs and respiratory muscles are affected. This leads to impaired mobility and breathing problems. Patients commonly die within a few years after the symptoms emerged. In rare cases, of which the British physicist Stephen Hawking is the most notable, patients can live with the disease for a long time. In Germany estimates show over 150,000 patients suffering from ALS an average of 1 in 500 people.

Proteins gone astray

Over the last few years, there has been increasing evidence that ALS and FTD a form of dementia associated with changes in personality and social behaviour may have similar or even the same origins. The symptoms overlap and common factors have also been found at the microscopic level. In many cases, particles accumulate and form clumps in the patient's nerve cells: this applies particularly to the TDP-43 protein.

"Normally, this protein is located in the cell nucleus and is involved in processing genetic information," explains molecular biologist Dr. Bettina Schmid, who works at the DZNE Munich site and at LMU. "However, in cases of disease, TDP-43 accumulates outside the nucleus forming aggregates." Schmid explains that it is not yet clear whether these clumps are harmful. "However, the protein's normal function is clearly disrupted. It no longer reaches the nucleus to perform its actual task. There seems to be a relationship between this malfunction and the disease."

Studies on zebrafish

However, until now little was known about the function of TDP-43. What are the consequences when this protein becomes non-functional? In order to answer this question, the team led by Bettina Schmid cooperated with the research group of Prof. Christian Haass to investigate the larvae of specially bred zebrafish. Their genetic code had been modified in such a way that no TDP-43 was produced in the organism of the fish. The result: the young fish showed massive muscle wasting and died a few days after hatching. Moreover, the extensions of the nerve cells which control the muscles were abnormal.

"To some extent, these are symptoms typical of ALS and FTD. Therefore, a loss of function of TDP-43 does seem to play a critical role in the disease," says Haass, Site Speaker of the DZNE Munich Site and chair of Metabolic Biochemistry at LMU.

The study revealed one more finding which surprised the researchers: the blood flow of the fish was massively disturbed. "It is well known that circulatory disorders play a part in other forms of dementia, notably in the case of Alzheimer's," says Haass. "We now want to investigate whether such problems with blood flow may be a general problem of neurodegenerative diseases and whether such problems occur particularly in patients with ALS and FTD."

###

Original publication:

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron outgrowth", Bettina Schmid, Alexander Hruscha, Sebastian Hogl, Julia Banzhaf-Strathmann, Kathrin Strecker, Julie van der Zee, Mathias Teucke, Stefan Eimer, Jan Hegermann, Maike Kittelmann, Elisabeth Kremmer, Marc Cruts, Barbara Solchenberger, Laura Hasenkamp, Frauke van Bebber, Christine van Broeckhoven, Dieter Edbauer, Stefan F. Lichtenthaler, Christian Haass, PNAS.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 1-Mar-2013
[ | E-mail | Share ]

Contact: Dirk Frger
presse@dzne.de
0049-228-433-02260
Helmholtz Association of German Research Centres

Shortage of protein TDP-43 causes muscle wasting and stunted nerve cells

This press release is available in German.

A shortage of a protein called TDP-43 caused muscle wasting and stunted nerve cells. This finding supports the idea that malfunction of this protein plays a decisive role in ALS and FTD. The study is published in the "Proceedings of the National Academy of Sciences of the USA" (PNAS).

ALS is an incurable neurological disease which manifests as rapidly progressing muscle wasting. Both limbs and respiratory muscles are affected. This leads to impaired mobility and breathing problems. Patients commonly die within a few years after the symptoms emerged. In rare cases, of which the British physicist Stephen Hawking is the most notable, patients can live with the disease for a long time. In Germany estimates show over 150,000 patients suffering from ALS an average of 1 in 500 people.

Proteins gone astray

Over the last few years, there has been increasing evidence that ALS and FTD a form of dementia associated with changes in personality and social behaviour may have similar or even the same origins. The symptoms overlap and common factors have also been found at the microscopic level. In many cases, particles accumulate and form clumps in the patient's nerve cells: this applies particularly to the TDP-43 protein.

"Normally, this protein is located in the cell nucleus and is involved in processing genetic information," explains molecular biologist Dr. Bettina Schmid, who works at the DZNE Munich site and at LMU. "However, in cases of disease, TDP-43 accumulates outside the nucleus forming aggregates." Schmid explains that it is not yet clear whether these clumps are harmful. "However, the protein's normal function is clearly disrupted. It no longer reaches the nucleus to perform its actual task. There seems to be a relationship between this malfunction and the disease."

Studies on zebrafish

However, until now little was known about the function of TDP-43. What are the consequences when this protein becomes non-functional? In order to answer this question, the team led by Bettina Schmid cooperated with the research group of Prof. Christian Haass to investigate the larvae of specially bred zebrafish. Their genetic code had been modified in such a way that no TDP-43 was produced in the organism of the fish. The result: the young fish showed massive muscle wasting and died a few days after hatching. Moreover, the extensions of the nerve cells which control the muscles were abnormal.

"To some extent, these are symptoms typical of ALS and FTD. Therefore, a loss of function of TDP-43 does seem to play a critical role in the disease," says Haass, Site Speaker of the DZNE Munich Site and chair of Metabolic Biochemistry at LMU.

The study revealed one more finding which surprised the researchers: the blood flow of the fish was massively disturbed. "It is well known that circulatory disorders play a part in other forms of dementia, notably in the case of Alzheimer's," says Haass. "We now want to investigate whether such problems with blood flow may be a general problem of neurodegenerative diseases and whether such problems occur particularly in patients with ALS and FTD."

###

Original publication:

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron outgrowth", Bettina Schmid, Alexander Hruscha, Sebastian Hogl, Julia Banzhaf-Strathmann, Kathrin Strecker, Julie van der Zee, Mathias Teucke, Stefan Eimer, Jan Hegermann, Maike Kittelmann, Elisabeth Kremmer, Marc Cruts, Barbara Solchenberger, Laura Hasenkamp, Frauke van Bebber, Christine van Broeckhoven, Dieter Edbauer, Stefan F. Lichtenthaler, Christian Haass, PNAS.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-03/haog-mmn030113.php

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SF only team with no black players

SCOTTSDALE, Ariz. ? One of the highlights of the spring is when Willie Mays arrives and sits at his customary table in the Scottsdale Stadium clubhouse, and starts chirping at Mike Murphy.

This year, the moment came with a bit of melancholy.

That?s because as I looked around the room, I realized that Mays, and his assistant, were the only people of African-American heritage in it.

We know the trends. You?ve heard about them for a long time. The percentage of African-Americans in baseball, which peaked at close to 30 percent in the 1970s, has dwindled down to single digits.

Sure, there have been times when the Giants did not have a single African-American on the roster. But no representation whatsoever in big league spring training? More than 70 players, and not one African-American in the room? That realization stunned me.

I spent a half-hour going through every roster, and sure enough, the Giants are the only major league organization with zero African-Americans in big league camp. Some teams have more representation than others, sure. The Atlanta Braves will feature three African-Americans in their starting outfield, with the Upton brothers and Jason Heyward. But each of the other 29 teams at least has one African-American player in camp.

This isn?t a Giants-centric phenomenon by any means, and I?m making no suggestion to that effect. The club has spent high draft picks on African-American players, including Wendell Fairley, Fred Lewis and others. And GM Brian Sabean certainly is open-minded to finding talent in all shapes and forms. This is the club that invested in Tim Lincecum and traded for Hunter Pence, after all.

If you look around the Giants clubhouse, you?ll see people of color. The Giants have a vibrant Latino culture, and that extends to their coaching staff with Roberto Kelly (from Panama), Hensley Meulens (Curacao), infield coach Jose Alguacil (Venezuela) and minor league coach Henry Cotto (Puerto Rico).

But no African-American players at all? From the organization that so shined because of Mays and McCovey and Monte Irvin?

I suppose I?m doing little more than making an observation here. There are myriad reasons for the declining numbers of African-Americans in baseball, few of them simple. I can?t pretend to tell you which reasons are the most important, or what should be done, or even if something needs to be done.

I mentioned my observation to Sabean and he is stunned as well. He is a firm believer that the decreasing number of college scholarships has a lot to do with African-American receiving fewer opportunities in baseball. If you?re not from an affluent background, how can you afford to take a partial scholarship when you could get a full ride playing football or basketball? The existence of traveling teams, summer leagues, etc. also make it so much harder for kids to be two- or three-sport stars like in the past. And if you stop playing baseball at a young age, you don't continue to get access to better coaching, you don't continue to hone your skills, etc. Baseball might be your best sport but you don't play it long enough to find out.

I don't buy the garbage that baseball is less lustrous than football or that baseball requires more work than basketball. I've always felt there are some underlying stereotypes in those arguments that I can't accept.

The only thing I know is that equality cannot happen without equal opportunity, and if baseball needs to do anything, it?s to work to provide opportunities for all young people of all backgrounds to continue playing the game if they are interested in doing so.?

Well, here's one more thing I know: Barring a trade or late signing, the Giants will stand on the baseline on April 15, Jackie Robinson Day, 66 years after the color barrier was broken, and they won?t have a single African-American player to reflect on it.

--

It was a hard-hitting day at Camelback Ranch and two-homer hero Brett Pill wasn?t the only one squaring it up. Brandon Belt doubled for his first hit of the spring, and Roger Kieschnick also put a charge in a double to the wall in center field.

[BAGGARLY:?Pill provides thrills as Giants rally to tie Dodgers]

Giants manager Bruce Bochy was glad to see it.

?The kids have been passive with the bats,? he said. ?We?d like to see them be a little more aggressive up there, see them letting it go.?

--

Defensive play of the day was first baseman Ricky Oropesa, making a really nice, twisting stop on a throw that was wide and in the dirt. I?m not sure how Oropesa stayed on the bag, but he did.

No question, Oropesa?s power is his best tool. The 2011 third-rounder out of USC will get a good test at Double-A Richmond this year. I hadn?t heard too much about his defense, but a play like that will open eyes.

--

Tim Lincecum said he was encouraged by his first start of the spring and Bochy concurred.

?Timmy threw well,? Bochy said. ?Pitching out of the stretch, he looked comfortable and had good stuff. He stayed in a consistent delivery with good rhythm. Occasionally he got out of sync last year, he knows it, and he?s worked on tightening it up. I think he should feel good about how he threw and where he wanted to throw the ball.?

--

Ramon Ramirez has a World Series ring from the 2010 club, but he probably isn?t in the lead to win the final spot in the Giants bullpen. Scott Proctor continues to look sharp while throwing the splitter he learned in Korea. Chad Gaudin is an experienced guy as well, and he threw two innings in his first appearance. He?ll be stretched out and could even make some starts.

Ramirez will have to perform to win a job, and while there?s a long way to go this spring, the three-run home run he served up Tuesday (to minor leaguer Alex Castellanos) was not a good beginning.

--

Apropos of nothing, but I was reminded today of last year?s first spring visit to Camelback Ranch. Melky Cabrera homered from both sides of the plate, and that?s when everyone started taking notice ? this guy was going to be a force for the Giants.

Nobody could?ve predicted how it would end up for him, though.

--

Cardinals manager Mike Matheny came out in strong support of a rule change to prevent collisions at home plate, which is a huge about-face for him. Just a year ago, I interviewed him on this very subject and he said he didn?t think the game should legislate against something that has long been a part of baseball.

He explained his position very well in this piece on MLB.com.

I asked Bochy if it was encouraging to hear about Matheny?s conversion.

?It is,? he said. ?There?s a catcher who?s been through it. He certainly has an understanding of what I?m talking about. I?m glad to hear that, and I?m hoping other guys step up. That?s what?s going to be needed to make a change.?

League vice president Joe Torre still needs convincing, but if the voices escalate, I do think the day will come fairly soon when plays at the plate are legislated a little nearer to plays at the other three bases.

And if that happens, if catchers are a little safer as a result, that will be a great legacy for Bochy to leave this game ? greater than winning two World Series rings, even.

Source: http://www.csnbayarea.com/blog/andrew-baggarly/extra-baggs-giants-only-club-no-african-americans-etc

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How growing support for gay rights restricts religious freedom

Politics in a free society shouldn't be used to stamp out the views of those who dissent from prevailing opinion

Hardly a week passes without a major story documenting the march of homosexuality into the American mainstream. In the latest development, more than 100 prominent members of the GOP ? a party that less than a decade ago spearheaded an effort to pass a constitutional amendment banning gay marriage ? have signed a legal brief urging the Supreme Court to declare that gay people have a constitutional right to marry. This follows on the heels of news that the Obama administration has filed its own brief with the high court in favor of overturning the 1996 Defense of Marriage Act, which defines marriage in federal law as a union between a man and woman.

We are living through an astonishing cultural and political sea change ? one that looks likely to expand significantly the frontiers of liberty and equality in the United States. That's something that rapidly expanding numbers of Americans are prepared to accept and even applaud. But not all of them. A significant number of our fellow citizens (between a third and a half) affirm traditionalist religious views about sex and marriage that preclude them from embracing the new order. Some of these traditionalists have begun to worry ? and not for frivolous reasons ? that the widespread recognition of same-sex marriage will be followed by a public campaign to stamp out their dissent from the emerging pro-gay consensus.

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Those who care about the fate of freedom in the United States must not allow this to happen.

Opponents of gay marriage ? as well as a range of fair-minded writers and legal scholars ? foresee several possible assaults on religious freedom. Some predict that clergy and religious communities will be forced to solemnize same-sex marriages. Others claim that preaching against homosexuality could be prosecuted under hate-crime statutes. Still others envision hospitals and universities affiliated with traditionalist religious institutions running into legal trouble for staying true to their principles and beliefs by refusing to recognize the marriages of same-sex couples. Finally, many traditionalists anticipate a future in which the nation's public schools treat the history of discrimination against homosexuals and their eventual acceptance into the mainstream of American life as perfectly analogous to the story of racial discrimination and the triumph of the movement for black civil rights. In that case, the government would be actively working to undermine the sexual morality that traditionalists wish to pass on to their children.

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Many supporters of gay rights will no doubt say that this is precisely what the government should be doing, since it has as much of an interest in weakening homophobia as it does in weakening racism. But this fails to acknowledge the very different roles of race and gender in the Abrahamic religious traditions. While various religious texts have been used to justify racism and slavery over the centuries, these texts do not command adherents to adopt these practices in the way that they appear to command obedience to a series of strict teachings about gender roles and sexual propriety. Which is to say that the attempt to use the public schools to stamp out homophobia is a far more profound challenge to the integrity of traditionalist religious beliefs than is the effort to drive out racism. If we want to avoid provoking a mass exodus of religious traditionalists from the public schools (and we should certainly want to avoid it), we must tread very cautiously in these matters, restraining the urge to educate traditionalists away from their deeply held religious convictions.? ? ? ? ??

But we must also go further, taking concrete, legal steps to guarantee that the religious freedom of traditionalists is recognized and protected. Why? Because the United States is a nation dedicated to the ideal of freedom ? and religious freedom is, in several senses, the first freedom. The Puritans settled New England to establish a political order that would guarantee religious liberty. Nearly 170 years later, James Madison began the Bill of Rights with a robust defense of religious freedom. To this day, the right of individuals to practice their faith ? and to pass it on to their children as they see fit, usually by participating in the life of privately organized religious communities and institutions ? serves as a foundational element of the nation's civic order.?

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It is our commitment to protecting individual rights that enables us to live together in relative peace, despite our deep disagreements about how to answer ultimate questions ? including the question of whether God exists, and if He does, how He wants us to live. When the government denies traditionalists the right to answer these questions as they wish, it uses illiberal means to impose liberal ends. And that should be considered unacceptable.? ? ? ? ? ??

In practical terms, this means that we need to build on what states such as Connecticut and New Hampshire have already begun to do: include passages or amendments in same-sex-marriage legislation that explicitly define and protect the religious freedom of sexual traditionalists. This doesn't mean that traditionalists should get their way on every matter; the law traditionally limits claims to religious freedom when members of a religious community provide services outside their faith tradition (like adoption or hospital care) or enter the commercial marketplace (by, say, leasing a catering hall for wedding receptions). In such cases, religious traditionalists might be forced to recognize the legal validity of same-sex marriages (while presumably continuing to judge them, on a personal level, as morally and spiritually null and void). But on the all-important matter of religious freedom (in both speech and practice), we need to write laws and regulations in such a way that they unambiguously protect the right of traditionalists to preach their beliefs about the evils of homosexuality and to pass those beliefs on to their children.?

SEE MORE: Would Caroline Kennedy make a good ambassador to Japan?

This may make some liberals uncomfortable. But civically speaking, it is no less important than advocating for homosexual rights. Politics in a free society shouldn't be used to stamp out the views of those who dissent from prevailing opinion. It should be used to defend the rights of the dissenters.

Damon Linker is a senior writing fellow at the University of Pennsylvania, a contributing editor at?The New Republic, and the author?of?The?Theocons?and?The Religious Test.?You can follow him on Twitter:?@DamonLinker.

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Source: http://news.yahoo.com/growing-support-gay-rights-restricts-religious-freedom-061500334.html

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