Sunday, April 21, 2013

NRA ardor, clout overwhelm gun-control groups, for now

By Andy Sullivan

WASHINGTON (Reuters) - As lawmakers gathered in the U.S. Senate on Wednesday to vote on a plan to expand background checks for gun buyers, staffers in the office of Alaska Democratic Senator Mark Begich fielded a steady stream of calls urging him to break with his party and vote against the measure.

Those callers got what they wanted: Begich voted no - one of four Democrats from gun-friendly states to do so - and the most ambitious gun-control push in two decades went down to defeat.

It was an impressive show of force by the National Rifle Association, which reaffirmed its reputation as one of Washington's most powerful interest groups by turning back one of President Barack Obama's top second-term priorities.

The NRA mobilized a disciplined, grassroots army that flooded Republican and conservative Democratic lawmakers' offices with phone calls and e-mails.

The NRA and its supporters also followed a tightly woven script that accused Obama of not following up on thousands of gun buyers each year who fail background checks under existing laws. The association's talking points, often repeated word for word by lawmakers and NRA supporters, cast the new background checks plan as an infringement on the constitutional right to bear arms of law-abiding citizens.

After the measure fell six votes short of the 60 votes it needed to advance in the 100-member Senate, Obama acknowledged that gun-control supporters have a way to go before they can match the sustained passion that has allowed the gun lobby to steadily loosen firearms laws over the past 18 years.

Now, with the push for gun control in a holding pattern on Capitol Hill, gun-control groups are vowing to meet Obama's challenge to beat the NRA at its own game.

Gun control has a deep-pocketed sponsor in New York City Mayor Michael Bloomberg, who spent $12 million on ads in March targeting key lawmakers.

Organizing for America, an advocacy group spawned from Obama's re-election campaign, plans to mount rallies to pressure lawmakers who voted against the bill.

Separately, the Progressive Change Campaign Committee, an independent liberal group, plans to run newspaper ads criticizing Montana Democratic Senator Max Baucus for voting against the bill, the first of what the group says could be many targeted pressure campaigns aimed at lawmakers who will face re-election next year.

That effort could backfire, analysts say.

The Democratic Party - which controls 55 seats in the Senate - needs conservative Democrats such as Begich and Baucus to win re-election next year in order to retain control of the chamber. Efforts to punish them for their vote could hand those seats to Republicans.

Going after Begich or Baucus would "blow up in their face," said Jim Manley, a former spokesman for Senate Democratic Leader Harry Reid. "They have to decide whether they want an issue or whether they want to win."

INTENSITY TRUMPS POPULARITY

As Wednesday's vote showed, the NRA can count on their 4.5 million members to leap into action when it counts. Gun-control groups have yet to match that type of enduring intensity.

"People who own guns care about guns," said Richard Feldman, a former NRA lobbyist who now heads a gun-rights group called Independent Firearm Owners of America that supported the background-check legislation.

"People who don't own guns, they have the same vote but they don't care about guns," he said.

Wednesday's vote was the NRA's toughest test in nearly 20 years.

The December massacre of 20 school children and six adults in Newtown, Connecticut, pushed gun control to the top of Obama's agenda and galvanized advocates such as Bloomberg.

The NRA also was coming off an election that called its influence into question. Only 5 percent of the $19 million the group spent on television ads and other forms of electoral communication in 2012 went toward winning candidates, according to the Center for Responsive Politics, which tracks political spending.

Demographic trends are working against the NRA as well. Fewer than one-third of U.S. households owned guns in 2011, down from 54 percent in 1977, according to the University of Chicago's General Social Survey.

The NRA's stance against expanding background checks to people who buy guns over the Internet and at gun shows, reversing its earlier support, put the NRA at odds with 80 percent to 90 percent of the public.

But as Wednesday's vote showed, a motivated minority that cares passionately about an issue often carries more weight in Washington than a majority that is not quite as focused on that single issue.

"It's intensity versus preference," said anti-tax activist Grover Norquist, a member of the NRA's board of directors. "While 90 percent will tell you, 'Sure, I'm for that,' 5 percent will really hate that, and on Election Day the only people who remember your position are the 5" percent, he said.

Gun-control advocates could make headway in the coming months by making enough noise at the grassroots level to let lawmakers such as Baucus and Begich know that they would not pay a significant price if they changed their minds, said Matt Bennett, a co-founder of the centrist Democratic think tank Third Way.

That could allow the bill to come back up for another vote before the 2014 elections, he said.

"Showing a bit of anger is useful," Bennett said.

Perhaps, but after this week's vote, Baucus, for one, made clear that he believed that rural Montana voters would punish him if he supported a measure seen as limiting gun owners' rights.

Gun-control groups will have to match an NRA political machine that maintains a vigorous presence at all levels of government. In February alone, the group donated to three state legislature candidates in Rhode Island and 16 congressional candidates and campaign groups, according to federal records.

Despite the NRA's setbacks in last year's elections, the gun lobby's tactics and legislative success remain an imposing force, said Sheila Krumholz, executive director of the Center for Responsive Politics.

Gun-rights groups have donated $596,000 to the sitting members of the Senate since 2007, while gun-control groups have donated only $5,000.

The NRA and other gun-rights groups "are perennially among the most powerful interest groups in Washington," Krumholz said.

(Editing by David Lindsey and Eric Walsh)

Source: http://news.yahoo.com/nra-ardor-clout-overwhelm-gun-control-groups-now-053334584.html

real housewives of atlanta colton bo ryan the last waltz earth day activities mel gibson splunk

PFT: Ex-Steeler Harrison, Bengals agree to deal

pg2_g_polian_300Getty Images

In the 1998 NFL draft, Colts General Manager Bill Polian had a decision to make: Peyton Manning or Ryan Leaf? He chose right, and as a result his job in Indianapolis was safe as long Manning was there.

Now Polian is playing a different role, analyzing the draft for ESPN, and he was asked to pick the best quarterback in this year?s draft. Polian?s surprising answer? Oklahoma?s Landry Jones.

Polian said he attended the 2011 Oklahoma-Texas A&M game and watched Jones complete 18/38 passes for 255 yards, with two touchdowns and no interceptions, and Polian thought Jones compared favorably to Texas A&M quarterback Ryan Tannehill, who was last year?s No. 8 overall pick and is now the Dolphins? starter.

?He was a good one, and when he had a good supporting cast around him, he was great,? Polian said of Jones. ?I was at the game in Norman where he beat Tannehill head-to-head, in a very, very fierce wind. So this guy has been a winner, he?s got stature, he?s got arm strength ? he can make all the throws. He sees the field quite well, and he?s a natural leader.?

Polian acknowledged that there are concerns about Jones, including his lack of mobility, and he said he doesn?t see a Peyton Manning in this year?s draft. But he thinks if there?s a quarterback who?s going to make an instant impact for an NFL team in 2013, it?s Jones.

?I don?t think anybody in this group is going to be able to step in right away and lead the team, but if you ask me, who?s the guy who?s most ready, and who?s the guy who?s had the most winning experience, it would be Landry Jones,? Polian said.

From all indications, Polian?s view is a minority opinion ? most people think Geno Smith of West Virginia, E.J. Manuel of Florida State, Matt Barkley of USC and Ryan Nassib of Syracuse are all better prospects than Jones.

Source: http://profootballtalk.nbcsports.com/2013/04/19/james-harrison-agrees-to-terms-with-bengals/related/

pro bowl victoria azarenka Royal Rumble 2013 senior bowl norovirus Eclampsia Kendrick Lamar

Saturday, April 20, 2013

Second Boston Marathon bombing suspect arrested after day of lockdown (Washington Post)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/300328183?client_source=feed&format=rss

secret service scandal shea weber greystone sidney crosby at the drive in alternative minimum tax modeselektor

The Engadget Mobile Podcast, live at 12AM ET!

The Engadget Mobile Podcast, live at 1130PM ET!

Another week, another heavy dose of wireless news. Speaking of dosage, Myriam and Brad are on the mics again, and drugs will likely once again play a large role in the discourse -- though perhaps not as much as last week. Either way, it should be a fun show, so stay tuned. For all who can't make the late-night podcast, the recorded version should be up sometime tomorrow, and we hope to be back to our normal schedule next week!

PS. Our sponsor for this week's podcast is Audible, so go to audible.com/engadget to check out some great book titles while you listen to the show!

April 19, 2013 12:00 AM EDT

Filed under: ,

Comments

Source: http://www.engadget.com/2013/04/18/engadget-mobile-podcast/

dickens greg kelly cujo karen handel hangout todd haley kareem abdul jabbar

Yahoo Will Shut Down Upcoming, Deals, SMS Alerts, Kids, Some Of Mail To Focus On Apps You'll Use Daily

Yahoo AxeYahoo has just announced a change in strategy designed to prep it for the mobile age and let it concentrate on core products like the Mail and Weather apps it launched yesterday. Soon, it will shut down Upcoming, Deal, SMS Alerts, Yahoo Kids, Yahoo! Mail and Messenger feature phone (J2ME) apps, and some older versions of Yahoo! Mail. People simply don't have the bandwidth for dozens of apps, so best to do a few well.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/JPURC6hwrvk/

Sam Claflin Tony Farmer West Nile virus symptoms snooki amy schumer amy schumer Prince Harry Vegas pictures

Wednesday, April 17, 2013

Cell-permeable peptide shows promise for controlling cardiovascular disease

Wednesday, April 17, 2013

Atherosclerosis ? sometimes called "hardening of the arteries" ? is a leading cause of death and morbidity in Western countries. A cell-permeable peptide containing the NF-?B nuclear localization sequence (NLS) shows promise as a potential agent in controlling the development of atherosclerotic disease. This study is published in the May 2013 issue of The American Journal of Pathology.

Atherosclerosis is a chronic inflammatory disease of the arterial and vascular wall. The objective of many therapeutic compounds is to modulate atherogenesis ? the process that leads to the formation of fatty tissue-containing plaques that stick to the cell wall. Numerous cellular and molecular inflammatory components are involved in the disease process, and uncontrolled activation of pro-inflammatory transcription factors, such as nuclear factor-B (NF-?B), plays a significant role. Several NF-?B inhibitors are in phase II-III clinical trials against various inflammatory diseases, but most cardiovascular research is still in the preliminary laboratory experimental phase.

Investigators in Spain, the United States, the United Kingdom, and Germany studied the anti-inflammatory and atheroprotective effects of a cell-permeable peptide containing the NF-?B NLS. In vitro tests clearly established that NLS peptide blocks the nuclear import of activated NF-?B and inhibits NF-?B activation in vascular cells. These findings were corroborated in vivo in ApoE knockout mice, an experimental model relevant to human atherosclerosis. In these experiments, the mice were fed a high-fat diet and treated with either NLS peptide or vehicle (control group).

The results showed that systemic administration of NLS peptide reduced the nuclear NF-?B activity in vascular smooth muscle cells (VSMCs) and macrophages of aortic plaques of mice. More importantly, NLS peptide inhibited lesion development in mice either at the onset of atherosclerosis (early treatment) or after the development of advanced plaques (delayed treatment), without affecting serum cholesterol levels. The results also demonstrated that NLS peptide alters plaque composition and inflammation in atherosclerotic lesions.

"The NF-?B system is a crucial factor regulating the expression of genes in different steps of the atherosclerotic process, from early phases characterized by lipid modification, chemotaxis, adhesion of leukocytes, monocyte differentiation, foam cell formation, and inflammatory cytokine expression to more advanced lesions involving cell death, migration and proliferation of VSMCs, and fibrous cap formation," explained lead investigator Carmen Gomez-Guerrero, PhD, of the Renal and Vascular Inflammation Laboratory, IIS-Fundaci?n Jim?nez D?az, Autonoma University, Madrid, Spain.

"Our study demonstrates that targeting NF-?B nuclear translocation hampers inflammation and atherosclerosis development and identifies cell-permeable NLS peptide as a potential anti-atherosclerotic agent," she said. "These properties make cell-permeable NLS peptide a promising prevention/intervention strategy to inhibit inflammation in cardiovascular diseases."

###

Elsevier Health Sciences: http://www.elsevierhealth.com

Thanks to Elsevier Health Sciences for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 29 time(s).

Source: http://www.labspaces.net/127787/Cell_permeable_peptide_shows_promise_for_controlling_cardiovascular_disease

Pope John Paul II Galaxy S4 google reader carnival cruise nfl nfl lil wayne

UN: Rape, violence raging in C. African Republic

Apr 15 (Reuters) - Leading money winners on the 2013 PGATour on Monday (U.S. unless stated): 1. Tiger Woods $4,139,600 2. Brandt Snedeker $3,137,920 3. Matt Kuchar $2,442,389 4. Adam Scott (Australia) $2,100,469 5. Steve Stricker $1,935,340 6. Phil Mickelson $1,764,680 7. Dustin Johnson $1,748,907 8. Jason Day $1,659,565 9. Hunter Mahan $1,553,965 10. Keegan Bradley $1,430,347 11. Charles Howell III $1,393,806 12. John Merrick $1,375,757 13. Russell Henley $1,331,434 14. Michael Thompson $1,310,709 15. Kevin Streelman $1,310,343 16. Bill Haas $1,271,553 17. Billy Horschel $1,254,224 18. ...

Source: http://news.yahoo.com/un-rape-violence-raging-c-african-republic-134449200.html

belize adele lyrics best new artist 2012 grammys foo fighters nikki minaj album of the year